Gastric emptying time and gastric motility in patients with Parkinson's disease
Identifieur interne : 001920 ( Main/Corpus ); précédent : 001919; suivant : 001921Gastric emptying time and gastric motility in patients with Parkinson's disease
Auteurs : Ruth Hardoff ; Michael Sula ; Ada Tamir ; Adrian Soil ; Avi Front ; Samich Badarna ; Silvia Honigman ; Nir GiladiSource :
- Movement Disorders [ 0885-3185 ] ; 2001-11.
English descriptors
- KwdEn :
Abstract
Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1203
Links to Exploration step
ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title><author><name sortKey="Hardoff, Ruth" sort="Hardoff, Ruth" uniqKey="Hardoff R" first="Ruth" last="Hardoff">Ruth Hardoff</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Sula, Michael" sort="Sula, Michael" uniqKey="Sula M" first="Michael" last="Sula">Michael Sula</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Tamir, Ada" sort="Tamir, Ada" uniqKey="Tamir A" first="Ada" last="Tamir">Ada Tamir</name><affiliation><mods:affiliation>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Soil, Adrian" sort="Soil, Adrian" uniqKey="Soil A" first="Adrian" last="Soil">Adrian Soil</name><affiliation><mods:affiliation>Elgems (Elscint) Ltd., Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Front, Avi" sort="Front, Avi" uniqKey="Front A" first="Avi" last="Front">Avi Front</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Badarna, Samich" sort="Badarna, Samich" uniqKey="Badarna S" first="Samich" last="Badarna">Samich Badarna</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Honigman, Silvia" sort="Honigman, Silvia" uniqKey="Honigman S" first="Silvia" last="Honigman">Silvia Honigman</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1002/mds.1203</idno><idno type="url">https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001920</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title><author><name sortKey="Hardoff, Ruth" sort="Hardoff, Ruth" uniqKey="Hardoff R" first="Ruth" last="Hardoff">Ruth Hardoff</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Sula, Michael" sort="Sula, Michael" uniqKey="Sula M" first="Michael" last="Sula">Michael Sula</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Tamir, Ada" sort="Tamir, Ada" uniqKey="Tamir A" first="Ada" last="Tamir">Ada Tamir</name><affiliation><mods:affiliation>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Soil, Adrian" sort="Soil, Adrian" uniqKey="Soil A" first="Adrian" last="Soil">Adrian Soil</name><affiliation><mods:affiliation>Elgems (Elscint) Ltd., Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Front, Avi" sort="Front, Avi" uniqKey="Front A" first="Avi" last="Front">Avi Front</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Badarna, Samich" sort="Badarna, Samich" uniqKey="Badarna S" first="Samich" last="Badarna">Samich Badarna</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Honigman, Silvia" sort="Honigman, Silvia" uniqKey="Honigman S" first="Silvia" last="Honigman">Silvia Honigman</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-11">2001-11</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1041">1041</biblScope><biblScope unit="page" to="1047">1047</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">83D5C8B08639E0394D6512B8A7B2579BD14F4F02</idno><idno type="DOI">10.1002/mds.1203</idno><idno type="ArticleID">MDS1203</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>gastric emptying</term><term>gastric motility</term><term>motor response fluctuations</term><term>radionuclide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ruth Hardoff MD, DSc</name><affiliations><json:string>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Michael Sula MD</name><affiliations><json:string>Department of Neurology, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Ada Tamir DSc</name><affiliations><json:string>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Adrian Soil MSc</name><affiliations><json:string>Elgems (Elscint) Ltd., Haifa, Israel</json:string></affiliations></json:item><json:item><name>Avi Front MSc</name><affiliations><json:string>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Samich Badarna MD</name><affiliations><json:string>Department of Neurology, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Silvia Honigman MD</name><affiliations><json:string>Department of Neurology, Technion Institute of Technology, Haifa, Israel</json:string></affiliations></json:item><json:item><name>Nir Giladi MD</name><affiliations><json:string>Department of Neurology, Technion Institute of Technology, Haifa, Israel</json:string><json:string>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gastric emptying</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gastric motility</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>radionuclide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor response fluctuations</value></json:item></subject><articleId><json:string>MDS1203</json:string></articleId><language><json:string>eng</json:string></language><abstract>Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</abstract><qualityIndicators><score>7.466</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>2287</abstractCharCount><pdfWordCount>4466</pdfWordCount><pdfCharCount>27948</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>357</abstractWordCount></qualityIndicators><title>Gastric emptying time and gastric motility in patients with Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>16</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1047</last><first>1041</first></pages><issn><json:string>0885-3185</json:string></issn><issue>6</issue><subject><json:item><value>Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1002/mds.1203</json:string></doi><id>83D5C8B08639E0394D6512B8A7B2579BD14F4F02</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><availability><p>WILEY</p></availability><date>2001</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title><author><persName><forename type="first">Ruth</forename><surname>Hardoff</surname></persName><roleName type="degree">MD, DSc</roleName><note type="correspondence"><p>Correspondence: Rabin Medical Center, Beilinson Campus, Petach Tikvah 49100 Israel</p></note><affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Sula</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Ada</forename><surname>Tamir</surname></persName><roleName type="degree">DSc</roleName><affiliation>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Adrian</forename><surname>Soil</surname></persName><roleName type="degree">MSc</roleName><affiliation>Elgems (Elscint) Ltd., Haifa, Israel</affiliation></author><author><persName><forename type="first">Avi</forename><surname>Front</surname></persName><roleName type="degree">MSc</roleName><affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Samich</forename><surname>Badarna</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Silvia</forename><surname>Honigman</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation></author><author><persName><forename type="first">Nir</forename><surname>Giladi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation><affiliation>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-11"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1041">1041</biblScope><biblScope unit="page" to="1047">1047</biblScope></imprint></monogr><idno type="istex">83D5C8B08639E0394D6512B8A7B2579BD14F4F02</idno><idno type="DOI">10.1002/mds.1203</idno><idno type="ArticleID">MDS1203</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>gastric emptying</term></item><item><term>gastric motility</term></item><item><term>radionuclide</term></item><item><term>motor response fluctuations</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000-07-27">Received</change><change when="2001-02-01">Registration</change><change when="2001-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/83D5C8B08639E0394D6512B8A7B2579BD14F4F02/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/mds.v16:6</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2001-11">November 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.1203</doi><idGroup><id type="unit" value="MDS1203"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2001 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2000-07-27"></event><event type="manuscriptRevised" date="2001-01-18"></event><event type="manuscriptAccepted" date="2001-02-01"></event><event type="publishedOnlineEarlyUnpaginated" date="2001-11-07"></event><event type="firstOnline" date="2001-11-07"></event><event type="publishedOnlineFinalForm" date="2001-11-29"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1041</numbering><numbering type="pageLast">1047</numbering></numberingGroup><correspondenceTo>Rabin Medical Center, Beilinson Campus, Petach Tikvah 49100 Israel</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS1203.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="4276"></count></countGroup><titleGroup><title type="main" xml:lang="en">Gastric emptying time and gastric motility in patients with Parkinson's disease</title><title type="short" xml:lang="en">Gastric Motility in Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Ruth</givenNames><familyName>Hardoff</familyName><degrees>MD, DSc</degrees></personName><contactDetails><email>harduf@post.tau.ac.il</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Michael</givenNames><familyName>Sula</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ada</givenNames><familyName>Tamir</familyName><degrees>DSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Adrian</givenNames><familyName>Soil</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Avi</givenNames><familyName>Front</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Samich</givenNames><familyName>Badarna</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Silvia</givenNames><familyName>Honigman</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2" currentRef="#curr1"><personName><givenNames>Nir</givenNames><familyName>Giladi</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IL" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IL" type="organization"><unparsedAffiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IL" type="organization"><unparsedAffiliation>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IL" type="organization"><unparsedAffiliation>Elgems (Elscint) Ltd., Haifa, Israel</unparsedAffiliation></affiliation><affiliation xml:id="curr1" countryCode="IL"><unparsedAffiliation>Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">gastric emptying</keyword><keyword xml:id="kwd3">gastric motility</keyword><keyword xml:id="kwd4">radionuclide</keyword><keyword xml:id="kwd5">motor response fluctuations</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as <i>delay on</i> and <i>no on</i> in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of <i>T<sub>1/2</sub></i>) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE <i>T<sub>1/2</sub></i> of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the <i>on</i> state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the <i>on</i> state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Gastric emptying time and gastric motility in patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Gastric Motility in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Gastric emptying time and gastric motility in patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Ruth</namePart><namePart type="family">Hardoff</namePart><namePart type="termsOfAddress">MD, DSc</namePart><affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</affiliation><description>Correspondence: Rabin Medical Center, Beilinson Campus, Petach Tikvah 49100 Israel</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Sula</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ada</namePart><namePart type="family">Tamir</namePart><namePart type="termsOfAddress">DSc</namePart><affiliation>Community Medicine Carmel Medical Center, Technion Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adrian</namePart><namePart type="family">Soil</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Elgems (Elscint) Ltd., Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Avi</namePart><namePart type="family">Front</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Nuclear Medicine, Technion Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Samich</namePart><namePart type="family">Badarna</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silvia</namePart><namePart type="family">Honigman</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nir</namePart><namePart type="family">Giladi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technion Institute of Technology, Haifa, Israel</affiliation><affiliation>Current Address: Movement Disorders Unit, Department of Neurology, Tel‐Aviv Medical Center, Sackler Faculty of Medicine, Tel‐Aviv University, Tel‐Aviv, Israel.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-11</dateIssued><dateCaptured encoding="w3cdtf">2000-07-27</dateCaptured><dateValid encoding="w3cdtf">2001-02-01</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">28</extent><extent unit="words">4276</extent></physicalDescription><abstract lang="en">Gastrointestinal symptoms such as nausea, abdominal pain, and bloating are frequent complaints of patients with Parkinson's disease (PD). It has been postulated that impaired gastrointestinal function may contribute to the development of motor fluctuations such as delay on and no on in patients with PD. Gastrointestinal impaired function and symptoms may be associated with the disease itself or secondary to levodopa treatment. Thus, we assessed gastric emptying (GE) and gastric motility in PD patients to examine the association between clinical status and gastric function. GE and antral contraction (frequency and amplitude) were evaluated by scintigraphy in 29 patients with mild PD (Hoehn and Yahr [H&Y] stage 1.0–2.0); 22 patients with moderate PD (H&Y stage 2.5–3.0); and 22 healthy volunteers, following the ingestion of a labeled standard meal. Gastric emptying (mean ± SD of T1/2) and antral contraction were not significantly different between patients with mild PD (63.4 ± 28.8 minutes) and moderate PD (54.7 ± 25.5 minutes). In the control group, GE was 43.4 ± 10.8 minutes (range 29.0 – 61.0 minutes). The prevalence of delayed emptying (>61 minutes) was not significantly different in patients with mild disease (48.3%) as compared with patients with moderate disease (36.4%). Antral contraction, both frequency and amplitude, were not significantly different between patients with mild and moderate PD throughout the entire 100 minutes of the study. Untreated patients (n = 28) had mean GE T1/2 of 59 ± 30.6 minutes. Patients with smooth response to levodopa showed slower GE (n = 10; 73.6 ± 25.3 minutes), while treated patients with motor response fluctuations when tested at the on state (n = 13), had much faster GE (49.3 ± 16.2 minutes). This shortened GE in the on state was similar to the GE of normal volunteers. We conclude that gastric emptying time in patients with PD was delayed compared with control volunteers. It was even slower in patients treated with levodopa. This effect of levodopa treatment was reversed to pseudonormalization (normal GE) at the advanced stages of the disease, when patients developed motor response fluctuation. Other clinical features of PD were not associated with delayed gastric emptying. © 2001 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>gastric emptying</topic><topic>gastric motility</topic><topic>radionuclide</topic><topic>motor response fluctuations</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1041</start><end>1047</end><total>7</total></extent></part></relatedItem><identifier type="istex">83D5C8B08639E0394D6512B8A7B2579BD14F4F02</identifier><identifier type="DOI">10.1002/mds.1203</identifier><identifier type="ArticleID">MDS1203</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001920 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001920 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:83D5C8B08639E0394D6512B8A7B2579BD14F4F02
|texte= Gastric emptying time and gastric motility in patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |